子癇前症
Etiology[]
- Abnormal trophoblastic invasion
- Vasculopathy and inflammatory changes
- Nutritional factors: Zinc, calcium, Mg
Genetic Factors[]
- 高度遺傳性
- single gene model
- HLA-DR4
- Angiotension gene variant T 235
Pathogenesis[]
- vasospasm 造成 hypertension
- dysfunction of vascular endothelium
- NO synthesis increased
- endothelin-1 increased
- VEGF, PGF increased, but bioavailability 下降