醫學快紀
註冊
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子癇前症

Etiology[]

  • Abnormal trophoblastic invasion
  • Vasculopathy and inflammatory changes
  • Nutritional factors: Zinc, calcium, Mg

Genetic Factors[]

  • 高度遺傳性
  • single gene model
  • HLA-DR4
  • Angiotension gene variant T 235

Pathogenesis[]

  • vasospasm 造成 hypertension
  • dysfunction of vascular endothelium
  • NO synthesis increased
  • endothelin-1 increased
  • VEGF, PGF increased, but bioavailability 下降
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